Van Den Driessche or Vandendriessche is a surname. Notable people with the surname include:
Aurèle Vandendriessche (born 1932), Belgian long-distance runner
Carlos Van den Driessche (1901–1972), Belgian ice hockey player and rower
Franky Vandendriessche (born 1971), Belgian footballer
Pauline van den Driessche (born 1941), British-Canadian applied mathematician
Pol Van Den Driessche, Belgian politician
René Van Den Driessche (born 1928), Belgian fencer
Femke Van den Driessche, Belgian cyclist