Kalpana Kalpana (Editor)

Valerenic acid

Updated on
Edit
Like
Comment
Share on FacebookTweet on TwitterShare on LinkedInShare on Reddit
Formula
  
C15H22O2

Molar mass
  
234.334

Pubchem
  
6042891

Valerenic acid Mulzer Research Group Valerenic Acid

Valerenic acid is a sesquiterpenoid constituent of the essential oil of the Valerian plant. Not to be confused with valeric acid or valproic acid, which are related to each other and are anticonvulsants.

Valerenic acid httpsuploadwikimediaorgwikipediacommonsthu

Valerian is used as a herbal sedative which may be helpful in the treatment of insomnia.

The precise mechanism of this action has not been established. It is likely that several different components of the plant contribute to the effect. Valerenic acid is thought to be at least partly responsible for the sedative effects.

Valerenic acid Valepotrioate Valerenic Acid PharmaFactz

A study in 2004 found valerenic acid to act as a subtype-selective GABAA receptor positive allosteric modulator in neonatal rat brainstem preparations. The mechanism of this action could not be elucidated in this study.

Valerenic acid Valerenic acid CAS Number 3569106

A study in 2007 on GABA receptors of various composition, expressed in Xenopus oocytes (frog eggs), found valerenic acid to act mainly at α1β2 and α1β3 subtypes of these receptors. Only channels incorporating β2 or β3 subunits were stimulated by valerenic acid. Modulation of ion channel action was not significantly dependent on incorporation of α1, α2, α3 or α5 subunits.

Valerenic acid Valerenic acid C15H22O2 ChemSpider

A study in 2005, in vitro (binding assay and CHO-K1 cells), found valerian extract as well as valerenic acid to be 5-HT5A receptor (serotonin receptor) partial agonists. Part of the binding studies focused on the 5HT5A receptor, which is distributed in the suprachiasmatic nucleus. This is a tiny region of the brain, which is implicated in the sleep-wake cycle.

Valerenic acid Valerensure

A study in 2006 found valerian extract as well as valerenic acid to inhibit NF-κB, a protein complex that controls the transcription of DNA, in HeLa (cultured human cancer) cells. This was measured with the IL-6 / Luc (Interleukin-6 luciferase) assay as a measurement tool. The study mentioned that such inhibition may be connected to the reported anti-inflammatory action of the valerian plant.

Valerenic acid Valerenic acid Wikipedia

References

Valerenic acid Wikipedia


Similar Topics