Vail is a surname. Notable people with the surname include:
Aaron Vail (1796–1878), U.S. diplomat
Alfred Vail (1807–1859), U.S. machinist and inventor
Anna Murray Vail 1863–1955), U.S. botanist and first librarian of the New York Botanical Garden
Benjamin A. Vail (1844–1924), U.S. jurist and politician
Bob Vail (1881–1942), U.S. baseball pitcher
Charles H. Vail (1866–1924), U.S. Universalist clergyman, Christian socialist, political activist, and writer
Edwin Arnold Vail (1817–1885), Canadian physician and political figure
Eric Vail (born 1953), Canadian ice hockey player
Fred Vail (fl. 1903–1914), U.S. sports coach
George Vail (1809–1875), U.S. New Jersey politician
Harry Vail (died 1928), U.S. rowing coach
Henry Vail (1782–1853), U.S. New York State politician
Ira Vail (1893–1979), Canadian-born U.S. race car driver
Louis Vail (fl. 1894), U.S. football coach
Melville Vail (1906–1983), Canadian ice hockey player
Mike Vail (born 1951), U.S. baseball player
Myrtle Vail (also as Myrtle Damerel; 1888–1978), U.S. actress and writer
Nathan Russell Vail (1825–1888), U.S. mine operator, landowner, and politician
Pegeen Vail Guggenheim (1925–1967), Swiss-born French painter
Peter Vail (born 1930), U.S. geologist and geophysicist
Pyotr Vail (Пётр Львович Вайль; 1949–2009) Latvian-born Russian writer, editor, and radio executive
Rachel Vail (born 1966), U.S. children and young adults genre author
Richard B. Vail (1895–1955), U.S. Illinois politician
Silas Jones Vail (1818–1883), U.S. hatmaker and hymn composer
Stephen Vail (1780–1864), U.S. rail and metal forge businessman
Theodore Newton Vail (1845–1920), U.S. telephony industrialist
Theresa Vail (born 1990), U.S. beauty pageant contestant ("Miss Kansas" 2013)
Thomas Hubbard Vail (1821–1889), U.S. Episcopalian bishop
Tobi Vail (born 1969), U.S. musician, music critic, and feminist activist; formerly of the band Bikini Kill
William Berrian Vail (1823–1904), Canadian businessman and politician
William Vail (born 1950), U.S. set decorator and actor