Vaidyanathan is a surname. Notable people with the surname include:
P. P. Vaidyanathan, Professor of Electrical Engineering at Caltech
Ananth Vaidyanathan (born 1957), leading voice expert in India
Anu Vaidyanathan, Indian triathlete who competed in Ultraman
Arun Vaidyanathan, Indian-American film director, producer and screenwriter
Kunnakudi Vaidyanathan (1935–2008), Indian classical music violinist
L. Vaidyanathan, musicologist, music director and composer in the classical Carnatic music tradition
Nirupama Vaidyanathan, maiden name of Nirupama Sanjeev (born 1976), former Indian female professional tennis player
S.R.D. Vaidyanathan, Tamil musician
Sunil Vaidyanathan, author, photojournalist and environmentalist
Vaidyanathan Thirunavukkarasu or V.T. Arasu, distinguished himself through his contributions to various fields
