Vacuolar interface dermatitis

Vacuolar interface dermatitis (VAC, also known as liquefaction degeneration, vacuolar alteration or hydropic degeneration) is a dermatitis where degenerative changes occur at the dermoepidermal junction, with lymphophatic inflammation at the epidermis and dermis. This change is frequently found in lupus erythematosis, erythema multiforme and lichen sclerosis.