Uy is the surname of the following people
Alfonso A. Uy, Filipino-Chinese businessman
John James Uy (born 1987), Filipino/Chinese actor, artist, host and model
Liz Uy (born 1982), Filipino stylist and author
Matthew Uy (born 1990), American-born Filipino footballer
Rolando Uy (born 1954), Filipino politician
Steve Uy (born 1979), American comic book artist and writer
Vũ Quốc Uy (1920–1994), Vietnamese writer and cultural politician