Ussher is a surname. Notable people with the surname include:
Beverley Ussher (d. 1908), Australian residential architect
Elizabeth Tyrrell (née Ussher) (1619-1693), daughter of James Ussher
Henry Ussher (d. 1613), Archbishop of Armagh
Herbert Taylor Ussher, Governor of Tobago 1872-1875
James Ussher (1581-1656), Irish archbishop and theologian
Jane Ussher, New Zealand photographer
John Ussher (died 1741), Irish MP
John Ussher (1703–1749), Irish MP
Johnny Ussher (1830-1879), Canadian frontiersman
Kitty Ussher (born 1971), British Labour Member of Parliament
Richard J. Ussher (1841-1913), Irish ornithologist
St George Ussher (d. 1775), later St George St George, 1st Baron St George
