EC number 2.7.1.48 IntEnz IntEnz view ExPASy NiceZyme view | CAS number 9026-39-5 BRENDA BRENDA entry KEGG KEGG entry | |
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In enzymology, an uridine kinase (EC 2.7.1.48) is an enzyme that catalyzes the chemical reaction
ATP + uridineThus, the two substrates of this enzyme are ATP and uridine, whereas its two products are ADP and UMP.
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:uridine 5'-phosphotransferase. Other names in common use include pyrimidine ribonucleoside kinase, uridine-cytidine kinase, uridine kinase (phosphorylating), and uridine phosphokinase. This enzyme participates in pyrimidine metabolism.
Structural studies
As of late 2007, 8 structures have been solved for this class of enzymes, with PDB accession codes 1UDW, 1UEI, 1UEJ, 1UFQ, 1UJ2, 1XRJ, 2JEO, and 2UVQ.