United States Senate elections, 1928

Gains and losses

Republicans gained five seats by defeating five Democratic incumbents:

1. Delaware: Democratic incumbent Thomas F. Bayard, Jr. lost re-election to Republican challenger John G. Townsend, Jr..
2. Maryland: Democratic incumbent William Cabell Bruce lost re-election to Republican challenger Phillips Lee Goldsborough.
3. New Jersey: Democratic incumbent Edward I. Edwards lost re-election to Republican challenger Hamilton F. Kean.
4. Rhode Island: Democratic incumbent Peter G. Gerry lost re-election to Republican challenger Felix Hebert.
5. West Virginia: Democratic incumbent Matthew M. Neely lost re-election to Republican challenger Henry D. Hatfield.

Republicans gained one seat from a Democratic incumbent appointee who had lost nomination:

1. Ohio (Special): Democratic incumbent appointee Cyrus Locher lost nomination to Graham P. Hunt to finish the term. Hunt then lost the general election to Republican Theodore E. Burton.

Republicans gained one seat from a retiring Democratic incumbent:

1. Missouri: Democratic incumbent James A. Reed retired and was replaced by Republican Roscoe C. Patterson.

Republicans gained one seat from a vacancy:

1. Illinois (Special): The Senate refused to seat Republican incumbent Frank L. Smith after his 1926 election. He resigned February 9, 1928, leaving the seat vacant. Republican Otis F. Glenn won a special election to finish the term ending March 3, 1933.

Republicans held two seats from retiring Republican incumbents:

1. Connecticut: Republican incumbent George P. McLean retired and was replaced by Republican Frederic C. Walcott.

Democrats gained no seats.

Democrats held 1 seat from a retiring Democratic incumbent:

1. Texas: Democratic incumbent Earle Bradford Mayfield retired and was replaced by Democrat Tom Connally.