Ubaldini is an Italian surname. Notable people with the surname include:
Migliorino Ubaldini (active 1548), Italian military engineer working in Scotland
Petruccio Ubaldini (1524–1600), Italian calligraphist and illuminator on vellum who worked in England
Roberto Ubaldini (1581–1635), bishop and cardinal of the Catholic Church
Saúl Ubaldini (1936–2006), Argentine labor leader and parliamentarian for the Peronist Justicialist Party