Entrez 10600 | Ensembl ENSG00000156256 | |
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Aliases USP16, UBP-M, UBPM, ubiquitin specific peptidase 16 External IDs MGI: 1921362 HomoloGene: 38183 GeneCards: USP16 |
Ubiquitin carboxyl-terminal hydrolase 16 is an enzyme that in humans is encoded by the USP16 gene.
This gene encodes a deubiquitinating enzyme that is phosphorylated at the onset of mitosis and then dephosphorylated at the metaphase/anaphase transition. It can deubiquitinate H2A, one of two major ubiquitinated proteins of chromatin, in vitro and a mutant form of the protein was shown to block cell division. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
References
USP16 Wikipedia(Text) CC BY-SA