EC number 2.7.4.22 IntEnz IntEnz view ExPASy NiceZyme view | CAS number 9036-23-1 BRENDA BRENDA entry KEGG KEGG entry | |
In enzymology, an UMP kinase (EC 2.7.4.22) is an enzyme that catalyzes the chemical reaction
ATP + UMPThus, the two substrates of this enzyme are ATP and UMP, whereas its two products are ADP and UDP.
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with a phosphate group as acceptor. The systematic name of this enzyme class is ATP:UMP phosphotransferase. Other names in common use include uridylate kinase, UMPK, uridine monophosphate kinase, PyrH, UMP-kinase, and SmbA. This enzyme participates in pyrimidine metabolism.
Structural studies
As of March 2010, 19 structures have been solved for this class of enzymes, and are deposited in the PDB. All have a 3-layer (aba) sandwich) architecture (CATH code 3.40.1160.10). These include accession codes 2J4J, 2J4K, 2J4L, and 2VA1.
Search for all UMP Kinases in the PDB using the enzyme Browser at PDBe. (input the EC number)