UH 232

UH-232 ((+)-UH232) is a drug which acts as a subtype selective mixed agonist-antagonist for dopamine receptors, acting as a weak partial agonist at the D₃ subtype, and an antagonist at D₂Sh autoreceptors on dopaminergic nerve terminals. This causes dopamine release in the brain and has a stimulant effect, as well as blocking the behavioural effects of cocaine. It was trialled for the treatment of schizophrenia but unexpectedly caused symptoms to become worse.