Entrez 7368 | Ensembl ENSG00000174607 | |
Aliases UGT8, CGT, UGT4, UDP glycosyltransferase 8 External IDs MGI: 109522 HomoloGene: 20715 GeneCards: UGT8 | ||
2-hydroxyacylsphingosine 1-beta-galactosyltransferase is an enzyme that in humans is encoded by the UGT8 gene.
Function
Galactocerebrosides are abundant sphingolipids of the myelin membrane of the central nervous system and peripheral nervous system and are also present in small amounts in kidney. The key enzymatic step in the biosynthesis of galactocerebrosides consists of the transfer of galactose to ceramide catalyzed by UDP-galactose ceramide galactosyltransferase (CGT, EC 2.4.1.45). The enzyme encoded by the CGT gene is the first involved in complex lipid biosynthesis in the myelinating oligodendrocyte.
References
UGT8 Wikipedia(Text) CC BY-SA