UDP N acetylglucosamine 6 dehydrogenase

In enzymology, an UDP-N-acetylglucosamine 6-dehydrogenase (EC 1.1.1.136) is an enzyme that catalyzes the chemical reaction

UDP-N-acetyl-D-glucosamine + 2 NAD⁺ + H₂O ⇌ UDP-N-acetyl-2-amino-2-deoxy-D-glucuronate + 2 NADH + 2 H⁺

The 3 substrates of this enzyme are UDP-N-acetyl-D-glucosamine, NAD⁺, and H₂O, whereas its 3 products are UDP-N-acetyl-2-amino-2-deoxy-D-glucuronate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is UDP-N-acetyl-D-glucosamine:NAD⁺ 6-oxidoreductase. Other names in common use include uridine diphosphoacetylglucosamine dehydrogenase, UDP-acetylglucosamine dehydrogenase, UDP-2-acetamido-2-deoxy-D-glucose:NAD oxidoreductase, and UDP-GlcNAc dehydrogenase. This enzyme participates in aminosugars metabolism.