EC number 2.5.1.7 IntEnz IntEnz view ExPASy NiceZyme view | CAS number 9023-27-2 BRENDA BRENDA entry KEGG KEGG entry | |
In enzymology, an UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7) is an enzyme that catalyzes the chemical reaction
phosphoenolpyruvate + UDP-N-acetyl-D-glucosamineThus, the two substrates of this enzyme are phosphoenolpyruvate and UDP-N-acetyl-D-glucosamine, whereas its two products are phosphate and UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine.
This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is phosphoenolpyruvate:UDP-N-acetyl-D-glucosamine 1-carboxyvinyltransferase. This enzyme participates in amino sugars metabolism and glycan biosynthesis.
Structural studies
As of late 2007, 10 structures have been solved for this class of enzymes, with PDB accession codes 1A2N, 1DLG, 1EJC, 1EJD, 1EYN, 1NAW, 1Q3G, 1RYW, 1UAE, and 1YBG.