Species Human Entrez 23304 | Human Mouse Ensembl ENSG00000024048 | |
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Aliases UBR2, C6orf133, bA49A4.1, dJ242G1.1, dJ392M17.3, ubiquitin protein ligase E3 component n-recognin 2 External IDs MGI: 1861099 HomoloGene: 26151 GeneCards: UBR2 | ||
E3 ubiquitin-protein ligase UBR2 is an enzyme that in humans is encoded by the UBR2 gene.
Proteolysis by the ubiquitin-proteasome system controls the concentration of many regulatory proteins. The selectivity of ubiquitylation is determined by ubiquitin E3 ligases, which recognize the substrate's destabilization signal, or degron. The E3 ligase UBR2 participates in the N-end rule pathway, which targets proteins bearing an N-terminal degron, or N-degron (Kwon et al., 2003).[supplied by OMIM]
References
UBR2 Wikipedia(Text) CC BY-SA