Species Human Entrez 9040 | Human Mouse Ensembl ENSG00000130725 | |
 | ||
Aliases UBE2M, UBC-RS2, UBC12, hUbc12, ubiquitin conjugating enzyme E2 M External IDs MGI: 108278 HomoloGene: 2952 GeneCards: UBE2M | ||
NEDD8-conjugating enzyme Ubc12 is a protein that in humans is encoded by the UBE2M gene.
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is linked with a ubiquitin-like protein, NEDD8, which can be conjugated to cellular proteins, such as Cdc53/culin.
Interactions
UBE2M has been shown to interact with NEDD8, PRKAR1A and UBA3.
References
UBE2M Wikipedia(Text) CC BY-SA