Entrez 7319 | Ensembl ENSG00000077721 | |
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Aliases UBE2A, HHR6A, MRXS30, MRXSN, RAD6A, UBC2, ubiquitin conjugating enzyme E2 A External IDs MGI: 102959 HomoloGene: 68308 GeneCards: UBE2A |
Ubiquitin-conjugating enzyme E2 A is a protein that in humans is encoded by the UBE2A gene.
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Multiple alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms.
Interactions
UBE2A has been shown to interact with RAD18 and P53.
References
UBE2A Wikipedia(Text) CC BY-SA