Symbol U7 RNA type Gene; snRNA SO 0000274 | Rfam RF00066 Domain(s) Eukaryota | |
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The U7 small nuclear RNA (U7 snRNA) is an RNA molecule and a component of the small nuclear ribonucleoprotein complex (U7 snRNP). The U7 snRNA is required for histone pre-mRNA processing.
The 5' end of the U7 snRNA binds the HDE (Histone Downstream Element), a conserved purine-rich region, located 15 nucleotides downstream the histone mRNA cleavage site. The binding of the HDE region by the U7 snRNA, through complementary base-pairing, is an important step for the future recruitment of cleavage factors during histone pre-mRNA processing.
References
U7 small nuclear RNA Wikipedia(Text) CC BY-SA