Twardzik is a surname. Notable people with the surname include:
Dan Twardzik (born 1991), Czech footballer with Motherwell
Dave Twardzik (born 1950), American basketball player
Dick Twardzik (1931–1955), American jazz pianist
Filip Twardzik (born 1993), Czech footballer with Celtic
Patrik Twardzik (born 1993), Czech footballer with Livingston
René Twardzik (born 1970), Czech retired footballer