Tupou is a common surname in the Pacific Islands. It may refer to:
Anthony Tupou, Australian Rugby League player
Bill Tupou, New Zealand Rugby League player
Daniel Tupou, Australian Rugby League player
Fenuki Tupou, American football offensive lineman
Tame Tupou, New Zealand rugby league footballer
Will Tupou, New Zealand professional rugby footballer
Willie Tupou, Australian rugby league footballer
Several kings of Tonga
George Tupou I
George Tupou II
Sālote Tupou III
Tāufaʻāhau Tupou IV
George Tupou V
Tupou VI
