Harman Patil (Editor)

Tubulin—tyrosine ligase

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Covid-19
EC number  6.3.2.25
IntEnz  IntEnz view
ExPASy  NiceZyme view
CAS number  60321-03-1
BRENDA  BRENDA entry
KEGG  KEGG entry

In enzymology, a tubulin-tyrosine ligase (EC 6.3.2.25) is an enzyme that catalyzes the chemical reaction

ATP + detyrosinated alpha-tubulin + L-tyrosine alpha-tubulin + ADP + phosphate

The 3 substrates of this enzyme are ATP, detyrosinated alpha-tubulin, and L-tyrosine, whereas its 3 products are alpha-tubulin, ADP, and phosphate.

This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-amino-acid ligases (peptide synthases). The systematic name of this enzyme class is alpha-tubulin:L-tyrosine ligase (ADP-forming).

References

Tubulin—tyrosine ligase Wikipedia


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