Tsintsadze (Georgian: ცინცაძე) is a Noble family. Notable people with the surname include:
Dito Tsintsadze (born 1957), Georgian film director and screenwriter
Giorgi Tsintsadze (born 1986), Georgian basketball player
Irakli Tsintsadze (born 1964), Georgian composer
Kalistrate Tsintsadze (Callistratus of Georgia; 1866–1952), Catholicos-Patriarch of All Georgia
Kote Tsintsadze (1887–1930), Georgian communist politician
Sulkhan Tsintsadze (1925–1991), Georgian composer