Trussell is a surname. Notable people with the surname include:
Colin Trussell (born 1948), English former football referee from Crosby, LiverpoolEdmund Trussell, MP for Northamptonshire in 1330John Trussell, MP for Northamptonshire in 1404 and 1414John Trussell (1575-1648), English Historical WriterSir William Trussell (died 1346), Speaker of the House of Commons who informed Edward II of Parliament's vote of no confidence in him and became Edward III's Secretary and emissary overseasWilliam Trussell (died 1364), son of the above. Receiver of the Chamber in 1333William Trussell, MP for Leicestershire in 1421William Trussell, MP for Leicestershire in 1472 and 1477