Trussell is a surname. Notable people with the surname include:
Colin Trussell (born 1948), English former football referee from Crosby, Liverpool
Edmund Trussell, MP for Northamptonshire in 1330
John Trussell, MP for Northamptonshire in 1404 and 1414
John Trussell (1575-1648), English Historical Writer
Sir William Trussell (died 1346), Speaker of the House of Commons who informed Edward II of Parliament's vote of no confidence in him and became Edward III's Secretary and emissary overseas
William Trussell (died 1364), son of the above. Receiver of the Chamber in 1333
William Trussell, MP for Leicestershire in 1421
William Trussell, MP for Leicestershire in 1472 and 1477
