Trujillo is a surname. Notable people with the surname include:
Alex Trujillo (born 1974), Puerto Rican boxerAlfonso López Trujillo (1935–2008), Colombian cardinalCésar Gaviria Trujillo (born 1947), Colombian presidentChad Trujillo (born 1973), American astronomerDiego Trujillo (born 1960), Colombian actorHéctor Trujillo (1908–2002), Dominican Republic presidentJustin Trujillo (born 1977), American Silent ActivistLuis Trujillo (born 1977), Peruvian footballerMaría Trujillo (born 1959), Mexican–American athleteMariano Trujillo (born 1977), Mexican footballerRafael Trujillo (1891–1961), Dominican Republic presidentRafael Trujillo (sailor) (born 1975), Spanish sailorRaoul Trujillo (born 1955), American actorRigoberto Trujillo (born 1978), Cuban judokaRobert Trujillo (born 1964), American musician, member of MetallicaSolomon Trujillo (born 1951), American business executiveStephen Trujillo, American soldierTony Trujillo (born 1982), American skateboarder