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Tropoelastin

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Tropoelastin is a water-soluble molecule with a molecular weight of approximately 72,000 daltons. Multiple tropoelastin molecules covalently bind together with crosslinks to form the protein elastin that is very prevalent in the body. There is only one gene for this molecule. However, alternative splicing does produce tissue specific elastin variants.

There are 36 small domains in Tropoelastin and each weighs about 2 kilodaltons. Within the exons, there are alternating hydrophobic and Lysine-rich domains that are important in forming Elastin. Tropoelastin does not undergo cleavage and formation of the microfibril is achieved by a self-association process termed coacervation.

Coacervation

Tropoelastin aggregates at physiological temperature due to interactions between hydrophobic domains. This process is reversible and thermodynamically controlled. The coacervate is stabilized by cross-linking via lysyl oxidase. The coacervate then becomes insoluble and the process is irreversible. It then condenses to form a cross-linked structure of 4 residues, either Desmosine or Isodesmosine.

Tropoelastin is unusual in that it exists in multiple forms, called polymorphs. Tropoelastin is not normally available in its native state, since it becomes crosslinked immediately after its synthesis by the cell and during its export into the extracellular matrix. Tropoelastin confers strength and elasticity to the skin and other organs in the body. A synthetic form of human tropoelastin is made by the Barcelona based biotech company Asterion Global Alliance S.L. through expression in Nicotiana Benthamiana plants that function as bio-factories to obtain human-like recombinant proteins. This form of Tropoelastin is currently being marketed in topical treatments in the field of dermatology and high-end skin care.

References

Tropoelastin Wikipedia


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