MedlinePlus a694019 Bioavailability VD: 20-30 Liters Molar mass 369.418 g/mol | ATC code P01AX07 (WHO) Biological half-life 11 to 12 hours CAS ID 52128-35-5 | |
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AHFS/Drugs.com Consumer Drug Information Metabolism | ||
Trimetrexate is a quinazoline derivative. It is a dihydrofolate reductase inhibitor.
Uses
It has been used with leucovorin in treating pneumocystis pneumonia.
It has been investigated for use in treating leiomyosarcoma. It is a methotrexate (MTX) analog that is active against transport-deficient MTX-resistant tumor cells that overcome the acquired and natural resistance to methotrexate. Other uses include skin lymphoma.
References
Trimetrexate Wikipedia(Text) CC BY-SA