Molar mass 224.19 g/mol Pubchem 13345 | Formula C8H17O5P | |
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Boiling point 142 to 145 °C (288 to 293 °F; 415 to 418 K) at 9 mmHg | ||
Triethyl phosphonoacetate is a reagent for organic synthesis used in the Horner-Wadsworth-Emmons reaction (HWE) or the Horner-Emmons modification.
Triethyl phosphonoacetate can be added dropwise to sodium methoxide solution to prepare a phosphonate ylide. It has an acidic proton that can easily be abstracted by a weak base. When used in an HWE reaction with a carbonyl the resulting alkene formed is usually the E alkene, and is generated with excellent regioselectivity.
References
Triethyl phosphonoacetate Wikipedia(Text) CC BY-SA