Samiksha Jaiswal (Editor)

Transcobalamin

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Symbol
  
TCN1

HUGO
  
11652

RefSeq
  
NM_001062

Entrez
  
6947

OMIM
  
189905

UniProt
  
P20061

Transcobalamins are carrier proteins which bind cobalamin (B12).

Types

  • Transcobalamin I (TCN1), also known as haptocorrin, R-factor, and R-protein, is a glycoprotein produced by the salivary glands of the mouth. It primarily serves to protect cobalamin (Vitamin B12) from acid degradation in the stomach by producing a Haptocorrin-Vitamin B12 complex. Once the complex has traveled to the more neutral duodenum, pancreatic proteases degrade haptocorrin, releasing free cobalamin, which now binds to intrinsic factor for absorption by ileal enterocytes.
  • Transcobalamin II (TCN2) binds cobalamin once it has been uptaken by enterocytes of the terminal ileum and the "Intrinsic Factor-Vitamin B12" complex has been degraded. The TCII-Vit B12 complex then enters portal circulation and is processed in the liver.

    • References

    Transcobalamin Wikipedia
    (Text) CC BY-SA