EC number 2.5.1.11 IntEnz IntEnz view ExPASy NiceZyme view | CAS number 64763-52-6 BRENDA BRENDA entry KEGG KEGG entry | |
In enzymology, a trans-octaprenyltranstransferase (EC 2.5.1.11) is an enzyme that catalyzes the chemical reaction
all-trans-octaprenyl diphosphate + isopentenyl diphosphateThus, the 2 substrates of this enzyme are all-trans-octaprenyl diphosphate and isopentenyl diphosphate, whereas its two products are diphosphate and all-trans-nonaprenyl diphosphate.
This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is (E)-octaprenyl-diphosphate:isopentenyl-diphosphate octaprenyltranstransferase. Other names in common use include all-trans-nonaprenyl-diphosphate synthase, solanesyl-diphosphate synthase, solanesyl pyrophosphate synthetase, SPP synthase, nonaprenyl pyrophosphate synthetase, polyprenylpyrophosphate synthetase, terpenoidallyltransferase, terpenyl pyrophosphate synthetase, trans-octaprenyltranstransferase, and trans-prenyltransferase. This enzyme participates in biosynthesis of steroids.
Structural studies
As of late 2007, 16 structures have been solved for this class of enzymes, with PDB accession codes 1V4E, 1V4H, 1V4I, 1V4J, 1V4K, 1VG2, 1VG3, 1VG4, 1VG6, 1VG7, 1WKZ, 1WL0, 1WL1, 1WL2, 1WL3, and 2AZL.