EC number 2.5.1.30 IntEnz IntEnz view ExPASy NiceZyme view | CAS number 74506-59-5 BRENDA BRENDA entry KEGG KEGG entry | |
In enzymology, a trans-hexaprenyltranstransferase (EC 2.5.1.30) is an enzyme that catalyzes the chemical reaction
all-trans-hexaprenyl diphosphate + isopentenyl diphosphateThus, the two substrates of this enzyme are all-trans-hexaprenyl diphosphate and isopentenyl diphosphate, whereas its two products are diphosphate and all-trans-heptaprenyl diphosphate.
This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is all-trans-hexaprenyl-diphosphate:isopentenyl-diphosphate hexaprenyltranstransferase. Other names in common use include all-trans-heptaprenyl-diphosphate synthase, heptaprenyl pyrophosphate synthase, heptaprenyl diphosphate synthase, and heptaprenyl pyrophosphate synthetase. This enzyme participates in biosynthesis of steroids.
Structural studies
As of late 2007, 11 structures have been solved for this class of enzymes, with PDB accession codes 2E8T, 2E8U, 2E8V, 2E8W, 2E8X, 2E90, 2E91, 2E92, 2E93, 2E94, and 2E95.