EC number 1.3.1.38 IntEnz IntEnz view ExPASy NiceZyme view | CAS number 77649-64-0 BRENDA BRENDA entry KEGG KEGG entry | |
In enzymology, a trans-2-enoyl-CoA reductase (NADPH) (EC 1.3.1.38) is an enzyme that catalyzes the chemical reaction
trans-2,3-dehydroacyl-CoA + NADPH + H+Thus, the three substrates of this enzyme are trans-2,3-dehydroacyl-CoA, NADPH, and H+, whereas its two products are acyl-CoA and NADP+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is acyl-CoA:NADP+ trans-2-oxidoreductase. Other names in common use include NADPH-dependent trans-2-enoyl-CoA reductase, reductase, trans-enoyl coenzyme A, and trans-2-enoyl-CoA reductase (NADPH). This enzyme participates in fatty acid elongation in mitochondria and polyunsaturated fatty acid biosynthesis.
Structural studies
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1ZSY.