Routes of
administration By mouth CAS Number 41094-88-6 IUPHAR/BPS 5467 Route Oral administration ChemSpider ID 5321 | ATC code None PubChem CID 5522 Molar mass 304.387 g/mol Pubchem 5522 IUPHAR/BP 5467 | |
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Legal status In general: uncontrolled | ||
Tracazolate (ICI-136,753) is an anxiolytic drug which is used in scientific research. It is a pyrazolopyridine derivative, most closely related to pyrazolopyrimidine drugs such as zaleplon, and is one of a structurally diverse group of drugs known as the nonbenzodiazepines which act at the same receptor targets as benzodiazepines but have distinct chemical structures.
Tracazolate has primarily anxiolytic and anticonvulsant effects, with sedative and muscle relaxant effects only appearing at higher doses. It has a unique receptor binding profile involving allosteric modulation of several GABAA receptor subtypes, being selective for GABAA receptors containing α1 and β3 subunits, but exhibiting different effects depending on the third type of subunit making up the receptor complex.