Thomas James (c. 1573–1629) was an English librarian.
Thomas James may also refer to:
Tom James (born 1984), rower
Tom James (rugby player) (born 1987), Welsh rugby union footballer
Tom James (English footballer) (born 1988), English footballer
Tom James (Welsh footballer) (born 1996), Welsh footballer
Tommy James (American football) (1923–2007), American football cornerback
Thomas James (fl.1414), MP for Dunwich
Thomas James (died 1615), English politician
Thomas Lemuel James (1831–1916), banker and journalist who served as U.S. Postmaster General in 1881
Thomas James (sea captain) (1593–1635), English sea captain
Thomas James (minister) (1804–1891), former slave who wrote a short memoir
Thomas James (businessman), American businessman, chairman of Raymond James
Thomas Naum James (1925–2010), American cardiologist
Tommy James (born 1947), musician
T. G. H. James (1923–2009), British Egyptologist
Thomas James (bishop) (1786–1828), Anglican bishop in India
Thomas Shadrach James (1859–1946), school teacher, Methodist lay preacher, linguist and herbalist
Tommy Lee James, American country music songwriter and record producer