AHFS/Drugs.com Monograph License data US FDA: Tolazamide ATC code A10BB05 (WHO) CAS ID 1156-19-0 | MedlinePlus a682482 Routes ofadministration Oral Molar mass 311.401 g/mol ChEBI ID 9613 | |
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Pregnancycategory AU: CUS: C (Risk not ruled out) | ||
Tolazamide is an oral blood glucose lowering drug used for people with Type 2 diabetes. It is part of the sulfonylurea family (ATC A10BB).
Synthesis
para-Toluenesulfonamide is converted to its carbamate with ethyl chloroformate in the presence of a base. Heating that intermediate with azepane leads to the displacement of the ethoxy group and the formation of tolazemide:
References
Tolazamide Wikipedia(Text) CC BY-SA