Titcomb is a surname. Notable people with the surname include:
La Belle Titcomb (born 1876), American vaudeville performer
Brent Titcomb (born 1940), Canadian actor and musician
Ledell Titcomb (1866–1950), American Major League Baseball player
Jonathan Holt Titcomb (1819–1887), English clergyman and the first Anglican bishop of Rangoon
Liam Titcomb (born 1987), Canadian musician and actor
Mary Lemist Titcomb (1857–1932), thought leader in Library and Information Science
Mike Titcomb (1933–2008), rugby union referee
William Holt Yates Titcomb (1858–1930), English artist