Titcomb is a surname. Notable people with the surname include:
La Belle Titcomb (born 1876), American vaudeville performerBrent Titcomb (born 1940), Canadian actor and musicianLedell Titcomb (1866–1950), American Major League Baseball playerJonathan Holt Titcomb (1819–1887), English clergyman and the first Anglican bishop of RangoonLiam Titcomb (born 1987), Canadian musician and actorMary Lemist Titcomb (1857–1932), thought leader in Library and Information ScienceMike Titcomb (1933–2008), rugby union refereeWilliam Holt Yates Titcomb (1858–1930), English artist