Routes ofadministration IV, IM, SC, Other Metabolism Molar mass 223.34 g/mol | ATC code none Excretion Kidneys | |
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AHFS/Drugs.com International Drug Names Legal status AU: S4 (Prescription only)US: Schedule III | ||
Tiletamine is a dissociative anesthetic and pharmacologically classified as an NMDA receptor antagonist. It is related chemically to ketamine. Tiletamine hydrochloride exists as odourless white crystals.
It is used in veterinary medicine in the compound product Telazol (tiletamine/zolazepam, 50 mg/ml of each in 5 ml vial) as an injectable anesthetic for use in cats and dogs. It is sometimes used in combination with xylazine (Rompun) to tranquilize large mammals such as polar bears and wood bison. Telazol is the only commercially available tiletamine product in the United States. It is contraindicated in patients of an ASA score of III or greater and in animals with CNS signs, hyperthyroidism, cardiac disease, pancreatic or renal disease, pregnancy, glaucoma, or penetrating eye injuries.
Abuse of Telazol has been documented. Animal studies have also shown that tiletamine produces rewarding and reinforcing effects. Tiletamine products are classified as Schedule III controlled substances in the United States.