Puneet Varma (Editor)

Thymidylate synthase inhibitor

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Thymidylate synthase inhibitors are chemical agents which inhibit the enzyme thymidylate synthase and have potential as an anticancer chemotherapy. Five agents were in clinical trials in 2002: raltitrexed, pemetrexed, nolatrexed, ZD9331, and GS7904L.

Examples include

  • Raltitrexed, used for colorectal cancer since 1998
  • Fluorouracil, used for colorectal cancer
  • BGC 945
  • OSI-7904L
  • References

    Thymidylate synthase inhibitor Wikipedia


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