Thomas Scrope, 5th Baron Scrope of Masham (c. 1429-1475) was the third surviving son of John Scrope, 4th Baron Scrope of Masham. He succeeded to his father's title and estates in 1455 at the age of twenty-six, and was summoned to parliament from 9 October 1459 until 19 August 1472. At some point shortly after 18 March 1453, he had married Elizabeth Greystoke, daughter of Ralph, Lord Greystoke. Loyal to King Henry and the House of Lancaster in the early years of the Wars of the Roses, he was granted an annuity of twenty Marks in 1459, 'for services against the House of York.' He died in 1475; his widow, who married again, survived until the first year of the reign of Richard III, dying in December 1483.
Thomas Scrope and Elizabeth had four sons, all of whom inherited the barony. Thomas, his namesake and eldest, inherited on his father's death, and his brothers, due to repeated childlessness, inherited in turn; Henry, Ralph and Geoffrey. The fifth baron also had three daughters; Alice married Sir James Strangways, Margaret (who married a cousin), and Elizabeth.