Thomas Jefferson University's notable alumni include:
Charles Mertz Arbuthnot, American physician and pharmacist in Republic County, Kansas
Jose F. Caro (1948- ), Magee Professor of Medicine and the 16th Chairman of the Department, best known for his original research in obesity
Jacob Mendes Da Costa (1833–1900), American physician and pioneer in internal medicine
John Chalmers Da Costa (1863–1933), chair of the Jefferson Medical College Department of Surgery
Fisk Holbrook Day (1826–1903), American doctor and geologist.
Isaac Newton Evans (1827–1901), represented Pennsylvania's 7th congressional district in the United States House of Representatives from 1877 to 1879 and 1883 to 1887.
Carlos Juan Finlay (1833–1915), epidemiologist who discovered mosquitoes as vector of yellow fever
William S. Forbes (1831–1905), American physician and anatomist.
Robert Gallo (1937) Co-Discoverer of HIV
John H. Gibbon, Jr. (1903–1973), developed first successful heart-lung machine
Samuel D. Gross (1805–1884), pioneering American surgeon
John Martyn Harlow, American physician primarily remembered for his attendance on brain-injury survivor Phineas Gage.
Robert H. Hodsden (1806-1864), physician and Tennessee state legislator
Chevalier Jackson (1865–1958) pioneering American laryngologist
William Williams Keen (1837–1932) American surgeon who assisted in surgery on President Grover Cleveland
Simon Lord (1826–1893), member of the Wisconsin State Assembly and the Wisconsin State Senate
Harry Lott (1880–1949) Olympic gold medalist rower, graduated M.D. at Jefferson Medical College, returned as Professor
Marty Makary, physician, author, health policy educator and television medical commentator
S. Weir Mitchell, (1829–1914), American experimental physiologist and neurologist
Thomas J. Nasca, M.D., M.A.C.P., Current Chief Executive Director of the Accreditation Council for Graduate Medical Education which Accredits Residency Training Programs in the United States.
Ninian Pinkney, (1811–1877) U.S. Navy medical director, active during the American Civil War.
Orlando Plummer, (1836–1913) doctor and politician in Oregon.
David L. Reich, among the first to demonstrate the utility of electronic medical records for large-scale retrospective investigations demonstrating the association of intraoperative hemodynamic abnormalities with adverse postoperative outcomes.
George R. Robbins (1814–1875), represented New Jersey's 2nd congressional district in the United States House of Representatives from 1855 to 1859.
Arye Rosen, Academy Professor of Biomedical and Electrical Engineering in the School of Biomedical Engineering
J. Marion Sims (1813–1883), pioneering American gynecologist
Charles Skelton (1806–1879), represented New Jersey's 2nd congressional district in the United States House of Representatives from 1851 to 1855.
Edward Robinson Squibb (1819–1900), developed a process to produce pure ether and established E.R. Squibb & Sons, predecessor to Bristol-Myers Squibb.
