Thiosulfate—thiol sulfurtransferase

In enzymology, a thiosulfate-thiol sulfurtransferase (EC 2.8.1.3) is an enzyme that catalyzes the chemical reaction

thiosulfate + 2 glutathione ⇌ sulfite + glutathione disulfide + sulfide

Thus, the two substrates of this enzyme are thiosulfate and glutathione, whereas its 3 products are sulfite, glutathione disulfide, and sulfide.

This enzyme belongs to the family of transferases, specifically the sulfurtransferases, which transfer sulfur-containing groups. The systematic name of this enzyme class is thiosulfate:thiol sulfurtransferase. Other names in common use include glutathione-dependent thiosulfate reductase, sulfane reductase, and sulfane sulfurtransferase. This enzyme participates in glutathione metabolism.