Thiazole synthase

Updated on Dec 31, 2024

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EC number 2.8.1.10 BRENDA BRENDA entry KEGG KEGG entry		IntEnz IntEnz view ExPASy NiceZyme view MetaCyc metabolic pathway

Thiazole synthase (EC 2.8.1.10, thiG (gene)) is an enzyme with systematic name 1-deoxy-D-xylulose 5-phosphate:thiol sulfurtransferase. This enzyme catalyses the following chemical reaction

1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + thiocarboxy-adenylate-[sulfur-carrier protein ThiS] ⇌ 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS] + 2 H₂O

H₂S can provide the sulfur in vitro.

References

Thiazole synthase Wikipedia

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