ATC code R06AD06 (WHO) PubChem CID 6015 ECHA InfoCard 100.017.320 Molar mass 299.45 g/mol ChemSpider ID 5793 | CAS Number 2338-21-8 UNII IA16WBX317 Formula C18H23N2S Pubchem 6015 | |
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Thiazinamium metilsulfate (INN) or thiazinam is an antihistamine. The USAN is thiazinamium chloride (with a different counterion).
Synthesis
Since many of the uses of antihistamines involve conditions such as rashes, which should be treatable by local application, there is some rationale for developing drugs for topical use. The known side effects of antihistamines could in principle be avoided if the drug were functionalized to avoid systemic absorption. The known poor absorption of quat salts make such derivatives attractive for nonabsorbable antihistamines for topical use.
Thus, reaction of the well-known antihistaminic drug promethazine with methylchloride leads to thiazinamium chloride.
References
Thiazinamium metilsulfate Wikipedia(Text) CC BY-SA