Tezuka is a Japanese surname. Notable people with the surname include:
Chiharu Tezuka (born 1974) Japanese voice actorKatsumi Tezuka (born 1912) Japanese actorMachiko Tezuka (born 1986) Japanese gravure idol and bikini modelMakoto Tezuka (born 1961) Japanese film and anime directorOsamu Tezuka (1928–1989) Japanese manga artistRemi Tezuka (born 1980) Japanese tennis playerSatoshi Tezuka (born 1958) former Japanese soccer playerTakashi Tezuka (born 1960) Japanese video game designerTsuyoshi Tezuka (born 1975) Japanese race car driverFictional characters:
Kunimitsu Tezuka of The Prince of TennisRin Tezuka of Katawa ShoujoBeth Tezuka of Bravest Warriors