Tezuka is a Japanese surname. Notable people with the surname include:
Chiharu Tezuka (born 1974) Japanese voice actor
Katsumi Tezuka (born 1912) Japanese actor
Machiko Tezuka (born 1986) Japanese gravure idol and bikini model
Makoto Tezuka (born 1961) Japanese film and anime director
Osamu Tezuka (1928–1989) Japanese manga artist
Remi Tezuka (born 1980) Japanese tennis player
Satoshi Tezuka (born 1958) former Japanese soccer player
Takashi Tezuka (born 1960) Japanese video game designer
Tsuyoshi Tezuka (born 1975) Japanese race car driver
Fictional characters:
Kunimitsu Tezuka of The Prince of Tennis
Rin Tezuka of Katawa Shoujo
Beth Tezuka of Bravest Warriors
