Suvarna Garge (Editor)

Tetrahydroxynaphthalene reductase

Updated on
Edit
Like
Comment
Share on FacebookTweet on TwitterShare on LinkedInShare on Reddit
EC number
  
1.1.1.252

IntEnz
  
IntEnz view

ExPASy
  
NiceZyme view

CAS number
  
153702-05-7

BRENDA
  
BRENDA entry

KEGG
  
KEGG entry

In enzymology, a tetrahydroxynaphthalene reductase (EC 1.1.1.252) is an enzyme that catalyzes the chemical reaction

scytalone + NADP+ 1,3,6,8-tetrahydroxynaphthalene + NADPH + H+

Thus, the two substrates of this enzyme are scytalone and NADP+, whereas its 3 products are 1,3,6,8-tetrahydroxynaphthalene, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is scytalone:NADP+ Delta5-oxidoreductase.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1DOH, 1G0N, and 1G0O.

References

Tetrahydroxynaphthalene reductase Wikipedia