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American counter-terrorism officials express concern over both Taliban guest houses and Taliban safe houses.
The usual meaning of the term guest house is a place where visitors, who don't have local friends or relatives they can stay with, stay in areas where the hospitality industry is insufficiently developed to have hotels or motels. The usual meaning of the term guest house is not dissimilar to a bed and breakfast.
The term safe house, on the other hand, is used by intelligence officials, or by those involved in organized crime, and those who investigate them. It refers to an ordinary residence, that looks like it is the regular residence of an ordinary citizen, but is instead available to house intelligence sources, or organized crime participants, who need to "disappear".
In the American "War on Terrorism" American counter-terrorism officials seem to have conflated the two terms.