Puneet Varma (Editor)

Tagatose bisphosphate aldolase

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EC number
  
4.1.2.40

IntEnz
  
IntEnz view

ExPASy
  
NiceZyme view

CAS number
  
39433-95-9

BRENDA
  
BRENDA entry

KEGG
  
KEGG entry

In enzymology, a tagatose-bisphosphate aldolase (EC 4.1.2.40) is an enzyme that catalyzes the chemical reaction

D-tagatose 1,6-bisphosphate glycerone phosphate + D-glyceraldehyde 3-phosphate

Hence, this enzyme has one substrate, D-tagatose 1,6-bisphosphate, and two products, glycerone phosphate and D-glyceraldehyde 3-phosphate.

This enzyme belongs to the family of lyases, specifically the aldehyde-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is D-tagatose 1,6-bisphosphate D-glyceraldehyde-3-phosphate-lyase (glycerone-phosphate-forming). This enzyme is also called D-tagatose-1,6-bisphosphate triosephosphate lyase. This enzyme participates in galactose metabolism.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1GVF.

References

Tagatose-bisphosphate aldolase Wikipedia