Tabacco is a surname. Notable persons with the surname include:
Antonello Tabacco (born 1990), Italian football defender
Patrick Tabacco (born 1974), French rugby player
Giorgio Tabacco, harpsichordist who worked with Marina Scalafiotti
Joseph J. Tabacco, Jr., one of the directors of Overstock.com
John Tabacco, Staten Island politician
John Tabacco, American composer, music producer, vocalist